A proposed mechanism for progesterone regulation of trophoblast

Abstract
Background: Progesterone receptor act as ligand-inducible transcription factor in the respective
target cells by binding to specific progesterone response elements in the promoter of the target
genes. However, despite the lack of the classical progesterone response elements on matrix-
metalloproteinase-2 promoter, progesterone has been shown to decrease the activity of this
promoter
Presentation of the hypothesis: It has recently been suggested that in addition to interacting
with their classical co-activators and co-repressors, progesterone receptor are capable of binding
to several transcription factors. By interacting with other classes of transcription factors,
progesterone receptor is capable of transcriptional activation through the transcription factors
cognate DNA binding site.
Testing the hypothesis: Exploring transcription factors and transcription binding sites,
interacting with the progesterone receptor in modulation of the matrix-metalloproteinase
promoter.
Implications of the hypothesis: Identification of additional endogenous progesterone target
genes makes it possible to further explore the signaling mechanisms by which the hormone
regulates biological actions. Furthermore, the concepts of ligand-driven conformational diversity
and selective tissue actions can be exploited in the future for drug development which selectively
regulate orphan receptors from the nuclear receptor family.

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